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KMID : 0379520080240040263
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한국독성학회지
2008 Volume.24 No. 4 p.263 ~ p.271
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Effects of Exposure Period on the Developmental Toxicity of 2-Bromopropane in Sprague-Dawley Rats
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Shin In-Sik
Lee Jong-Chan
Kim Kang-Hyeon
Ahn Tai-Hwan
Bae Chun-Sik
Moon Chang-Jong
Kim Seong-Ho
Shin Dong-Ho
Kim Jong-Choon
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Abstract
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Recently we reported that 2-bromopropane (2-BP) has maternal toxicity, embryotoxicity, and teratogenicity in Sprague-Dawley rats. The aims of this study are to examine the potential effects of 2-BP administration on pregnant dams and embryo-fetal development, and to investigate the effects of metabolic activation induced by phenobarbital (PB) on developmental toxicities of 2-BP. Pregnant rats received 1000 ㎎/㎏/day subcutaneous 2-BP injections on gestational days (GD) 6 through 10 (Group Ⅱ and Group IIII) or 11 through 15 (Group Ⅳ). Pregnant rats in Group Ⅲ received an intraperitoneal PB injection once daily at 80 ㎎/㎏/day on GD 3 through 5 for induction of the liver metabolic enzyme system. Control rats received vehicle injections only on GD 6 through 15. All dams underwent caesarean sections on GD 20 and their fetuses were examined for external, visceral, and skeletal abnormalities. Significant adverse effects on pregnant dams and embryo-fetal development were observed in all the treatment groups, and the maternal and embryo-fetal effects of 2-BP observed in Group Ⅱ were higher than those seen in Group Ⅳ. Conversely, maternal and embryofetal developmental toxicities observed in Group Ⅲ were comparable to those seen in Group Ⅱ. These results suggest that the potential effects of 2-BP on pregnant dams and embryo-fetal development are more likely in the first half of organogenesis (days 6~10 of pregnancy) than in the second half and that the metabolic activation induced by PB pre-treatment did not modify the developmental toxic effects of 2-BP in rats.
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KEYWORD
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2-Bromopropane, Embryotoxicity, Teratogenicity, Susceptible period, Metabolic activation, Rats
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